Hair Loss Breakthrough PTD-DBM

Discover the cutting edge technology behind a peptide PTD-DBM that is changing lives!

We have found a protein that controls the hair growth and developed a new substance that promotes hair regeneration by controlling the function of the protein. The team led by Choi Kang-yeol of Yonsei University in South Korea, discovered that a protein called CXXC5 acts as negative regulator of the Wnt signalling pathway inside of a cell that is linked to follicle development and hair regeneration in adults.

Why do we loose our hair? The Hair Loss offender seems to be CXXC-type zinc finger protein 5 (CXXC5), which acts as a negative regulator on the Wnt/β-catenin pathway, which is linked to hair regeneration and wound healing. When CXXC5 binds with a protein called the Dishevelled protein, it prevents follicle development and hair regrowth. A new biomaterial acts as a negative regulator of the pathway interfering with this binding process. PTD-DBM was tested when applied to the bare skin of bald mice for 28 days, new follicles developed. In order to prevent CXXC5 , the team successfully developed a biochemical material called PTD-DBM. Disrupting the CXXC5-Dishevelled interaction with a competitor peptide activated the Wnt pathway and accelerated hair regrowth and wound-induced hair follicle neogenesis.

The positive effect of PTD-DBM on hair regeneration is shown in human hair follicle dermal papilla cells. The ideal treatment for hair regrowth is a three-prong approach. 

1. Wound-induced hair neogenesis, aka microneedling. This treatment for androgenetic alopecia involves rolling very very fine needles over the skin to puncture it. The devices are called dermarollers. They are hand held and rolled over the treatment area to cause a “wound” and help create follicle generation. Microneedling is common in treating the skin and has also been known to increases the production of collagen and other healing factors by causing slight trauma to the skin. 
2. CXXC5 targeting with PTD-DBM.
3. Valproic acid is used topically to activate the Wnt/β-catenin pathway.

So, there’s a threefold action to the treatment. The “wounds” from microneedling induce the generation of follicles; the valproic acid stimulates the cell pathway linked to the development of follicles; and the PTD-DBM prevents CXXC5 from interfering with the follicular development process. When the scientists combined these three processes, the hair grew back even quicker.

Product Use

Stop hair loss now and start regrowing it back. Both PTD-DBM and Valproic acid come in topical spray bottles and are applied to the scalp daily. Call AIM today for your appointment!